![]() ![]() Therefore, it is recommended that lovastatin be taken with food. Unlike the previous ones, the administration of lovastatin after a meal increases its plasma concentration by 50% compared to the fasting state. As for atorvastatin, it seems that a meal with a medium fat content may slightly reduce its absorption, while with simvastatin, it does not seem that this fact is relevant. This bioavailability reduction is also observed for fluvastatin, both water soluble, so it is recommended to space its administration with respect to meals at least 4 hours. ![]() When pravastatin is administered with food, its bioavailability is reduced by approximately 35% compared to that obtained in its administration before meals. In general, all statins reduce their absorption in the presence of food so that their administration is usually at night, before bedtime, and without food, although there are some exceptions. This is why the medication schedule is so important in these drugs. The absorption of a drug can be reduced, delayed, or increased by food consumption, as they share many physiological mechanisms and coincide with numerous organs. The interaction of statins at the level of absorption can translate into a decrease in the absorption of the drug by a change in pH, a variation in the speed of intestinal motility or the formation of complexes and/or chelates.Īll currently marketed statins are absorbed orally in a variable range (between 30% for lovastatin and 35% for pravastatin), so the influence of intake at the time of administration is very important to achieve an effect adequate therapeutic. ![]()
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